Chicken Alfredo Casserole

ByBrad Harris Published: Updated on

This Chicken Alfredo Casserole is a super easy recipe that delivers a huge flavor comfort food meal that the entire family will love. Creamy Alfredo sauce mixed with tender pasta and seasoned chicken will have them begging for more.

Chicken Alfredo Casserole in a white casserole dish with a serving on a black plate.
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Why You Will Love This Chicken Alfredo Casserole

This simple recipe does not need those canned soups or sauces. You can control what goes into this dish with just an extra step or two.

Furthermore, like us, you probably grab one of those $5 chickens from Sam’s or Costco, eat a bit, and have some leftovers. This dish is perfect for using that leftover chicken and getting an extra meal from that reasonable purchase.

Chicken Alfredo Casserole in a white casserole dish.

But the most important reason you will love this is its deliciousness. That creamy alfredo sauce, married with good pasta and hearty chicken, makes a great meal that everyone is going to love. Plus, it’s easy to prepare and is great for any meal for your family or for your company.

A great meal that doesn’t use crazy ingredients or cost a ton of money is a win in my book every time.

Ingredients needed

Simple ingredients make the best meals. This one is no different. There is nothing crazy here, and it is a great way to use up any leftover rotisserie chicken you may have lying around.

Ingredients needed to make Chicken Alfredo Casserole.

How To Make Chicken Alfredo Casserole

  • Preheat the oven to 375 degrees F. Also, prepare a 9×13″ baking dish by coating it with baking spray or a light film of butter. Cook the pasta to al dente and set aside.
  • Melt the butter in a large skillet over medium heat. Add the minced garlic and cook for 30 seconds to a minute until fragrant.
Melting butter in a skillet.
Adding garlic to butter in a skillet.
  • Add the flour to the skillet and whisk well to incorporate with the butter. Cook for a minute.
Butter, garlic, and flour cooking in a skillet.
Butter and garlic cooking in a skillet.
  • Add the heavy cream, milk, and nutmeg, whisking constantly. Continue to whisk until the sauce begins to thicken. Add 1/2 cup parmesan cheese and 1/2 cup mozzarella cheese to the sauce, stirring to combine well. Add any salt and pepper to taste once the cheese has been incorporated.
An alfredo sauce in a skillet.
Adding parmesan cheese to a sauce.
  • Place the cooked pasta in a large bowl and pour the sauce over the top. Mix well to coat evenly.
Chicken and pasta in a glass bowl.
Chicken Alfredo Casserole mixture in a glass bowl.
  • Pour the pasta and the sauce into the prepared 9×13″ pan and top with the remaining cheese.
Unbaked Chicken Alfredo Casserole in a white casserole dish.
Unbaked Chicken Alfredo Casserole in a white casserole dish.
  • Bake uncovered for 20-30 minutes until the cheese is nice and bubbly. If you want, throw it on broil to get your preferred level of browning on top (we do this).
Chicken Alfredo Casserole in a white casserole dish.
Chicken Alfredo Casserole in a white casserole dish.
  • Allow to set up for about 5 minutes, then optionally garnish with some chopped parsley, serve, and enjoy!
Chicken Alfredo Casserole in a white casserole dish.
Chicken Alfredo Casserole in a white casserole dish with a serving on a black plate.

Once you try this Chicken Alfredo Casserole, it’s sure to become a go-to favorite—quick, easy, and absolutely delicious!

Tips

Use Fresh Ingredients: While pre-cooked chicken is convenient, using freshly grilled or baked chicken can elevate the flavor.

Cook Pasta Al Dente: The pasta will continue cooking in the oven, so ensure it’s slightly undercooked before mixing it with the sauce.

Custom Browning: Broiling the casserole for a few minutes gives it a lovely golden top, adding both flavor and presentation.

Make it Ahead: This dish can be prepared a day in advance and refrigerated. Simply bake it when you’re ready to serve.

Variations

Vegetarian Option: Replace chicken with sautéed mushrooms, broccoli, or spinach for a veggie-friendly version.

Add Protein: Stir in crispy bacon or diced ham for an extra savory twist.

Cheese Swap: Try Gruyere or Fontina for a different cheesy flavor profile.

Spicy Kick: Add a pinch of red pepper flakes or diced jalapeños to the sauce for a touch of heat.

FAQs

Can I freeze Chicken Alfredo Casserole?

Yes! Assemble the casserole without baking, wrap it tightly with plastic wrap and aluminum foil, and freeze for up to 3 months. Thaw overnight in the refrigerator before baking.

Can I use a different type of pasta?

Absolutely! Fusilli, rigatoni, or farfalle work just as well as penne (we used rigatoni for ours). Choose a sturdy pasta that holds the sauce well.

What can I use instead of heavy cream?

Half-and-half or whole milk can work in a pinch, but the sauce may be slightly less creamy.

How do I prevent the sauce from becoming grainy?

Make sure to whisk the cheese into the sauce off the heat or at very low heat to prevent clumping.

Other Delicious Pasta Dishes

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Chicken Alfredo Casserole in a white casserole dish with a serving on a black plate.

Chicken Alfredo Casserole

Creamy Chicken Alfredo Casserole: quick, easy, and delicious with tender pasta, seasoned chicken, and no canned soups—perfect comfort food!
5 from 2 votes
Print Pin Rate
Course: Main
Cuisine: American
Prep Time: 20 minutes
Cook Time: 30 minutes
Servings: 6
Calories: 713kcal

Ingredients
 

  • 12 oz Penne pasta
  • 1 lb Chicken cooked, diced
  • 3 tbsp Butter unsalted
  • 2 tbsp Garlic minced
  • 2 tbsp Flour
  • 2 cup Milk
  • 1 cup Heavy cream
  • 1/4 tsp Nutmeg
  • 1 cup Parmesan cheese grated, divided
  • 2 cup Mozzarella cheese
  • Parsley chooped, garnish
  • Salt and pepper to taste

Instructions

  • Preheat oven to 375°F. Coat a 9×13″ baking dish with non-stick spray or butter.
  • Cook pasta al dente according to package instructions. Drain and set aside.
    12 oz Penne pasta
  • Melt butter in a large skillet over medium heat. Add minced garlic and cook until fragrant (30 seconds). Whisk in flour and cook for 1 minute.
    3 tbsp Butter, 2 tbsp Garlic, 2 tbsp Flour
  • Gradually whisk in milk, cream, and nutmeg. Cook until thickened. Stir in ½ cup parmesan and ½ cup mozzarella. Add salt and pepper to taste.
    2 cup Milk, 1 cup Heavy cream, 1/4 tsp Nutmeg, 1 cup Parmesan cheese, 2 cup Mozzarella cheese, Salt and pepper
  • In a large bowl, mix cooked pasta, diced chicken, and sauce until evenly coated.
    1 lb Chicken
  • Pour mixture into the prepared baking dish. Top with remaining cheese.
  • Bake uncovered for 20-30 minutes until bubbly. Optional: Broil for 1-2 minutes to brown the top.
  • Let rest for 5 minutes. Garnish with chopped parsley and serve.

Notes

Cool the casserole completely, then store leftovers in an airtight container in the refrigerator for up to 3 days. Reheat in the oven at 350°F or microwave until warmed through.

Nutrition

Calories: 713kcal | Carbohydrates: 51g | Protein: 33g | Fat: 42g | Saturated Fat: 24g | Polyunsaturated Fat: 3g | Monounsaturated Fat: 12g | Trans Fat: 0.3g | Cholesterol: 138mg | Sodium: 617mg | Potassium: 414mg | Fiber: 2g | Sugar: 7g | Vitamin A: 1323IU | Vitamin C: 2mg | Calcium: 535mg | Iron: 2mg

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5 from 2 votes (2 ratings without comment)

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